He made his MLB debut for the Astros in 2014. Enrique Hernandez then played for the Miami Marlins in 2014 and joined the Los Angeles Dodgers in 2015. He won a silver medal representing Puerto Rico in the 2017 Los Angeles World Baseball Classic. Enrique Hernandez signed a one year deal with the Dodgers in 2018 for $1.6 million. In 2018 he was selected to join the MLB All-Star team at the 2018 MLB Japan All-Star Series.