Nelson played for the Packers from 2008 to 2017 and for the Oakland Raiders in 2018. He won a Super Bowl championship with Green Bay and was a Pro Bowl selection in 2014 when he was also named a second-team All-Pro. Nelson was named NFL Comeback Player of the Year in 2016 and won the Best Comeback Athlete ESPY Award in 2017. He was the NFL receiving touchdowns leader in 2016.