She competed at the 2016 Rio Olympics where she won a silver medal as part of the women’s 4×100 freestyle relay. Manuel tied for a gold medal in the 100 meter freestyle event and co-set an Olympic record. She also became the first African-American woman to win a gold medal in an individual swimming event. Manuel holds world records in the 4 x 50 m medley relay mixed, 4 x 100 m medley relay mixed, and 4 x 100 m medley relay women.